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This utility allows you to lock the clock of the system to any desired time. This utility can help the user in locking the time in different time zones or in locking the system to any desired time zone. This utility is designed for Windows XP.Overexpression of exon 2 mutant (proband) smooth muscle myosin heavy chain leads to increased phosphorylation and activation of myosin light chain phosphatase.
The calponin homology (CH) domain of the myosin light chain phosphatase (MLCP) is required for binding to actin. A patient with hypertrophic cardiomyopathy carrying a homozygous mutation in exon 2 of the myosin heavy chain (MHC) gene has a cardiac phenotype distinct from those associated with a large deletion (exon 28) of the same gene. We sought to elucidate the basis of the distinct clinical phenotype. The human myosin heavy chain A or B isoform was overexpressed in HEK 293 cells and transiently transfected into rat neonatal cardiac myocytes. Activity of the MHC isoform and phosphorylation of MLCP (Myosin light chain phosphatase) in the myocytes were measured by gel electrophoresis and Western blot analysis. Cardiomyocytes overexpressing the patient’s mutant MHC isoform showed an increased level of phosphorylation and activation of MLCP compared to those transfected with the wild-type MHC isoform. MHC isoform (patient) overexpression and MLCP phosphorylation were not detected in the rat neonatal myocytes. The expression level of the non-muscle MHC isoform was lower in the patient’s myocytes compared to the rat neonatal myocytes. These findings may provide an explanation for the patient’s distinct phenotype.Q:

Angular2 rc.1 router not work

After upgrading my Angular 2.0.0 to rc.1,the routing won’t work.I have a main.ts
import { enableProdMode } from ‘@angular/core’;
import { platformBrowserDynamic } from ‘@angular/platform-browser-dynamic’;
import { AppModule } from ‘./app/app.module’;

if (environment.production) {

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KeyMacro is a powerful recording tool that can record anything at any time. The software utilizes the built-in microphone and camera to record all that you see and hear in real time. Not only can you record lectures, meetings, presentations, and demos, but you can also record your own voice and play it back later. With multiple languages available and a wide range of features, it’s no wonder why KeyMacro is a favorite among the young and old.


Record with a built-in mic and camera for easy multimedia capturing.
Record up to 120 minutes of high-quality audio and video.
More than 30 built-in templates to start recording straight away.
Multiple recording modes to capture the most suitable moments.
Save and organize the captured files in user-friendly folders.
Recorded audio and video can be previewed and edited in real time.
Save the recorded files in the cloud for instant sharing.
Supported audio formats: MP3, WAV, WMA, OGG, AAC, M4A.
Supported video formats: AVI, MOV, MP4, M4V, MKV, FLV, 3GP, WEBM, etc.


1. Record a meeting: start recording when you are in the middle of a meeting, you will never miss out any important things.
2. Record a seminar: record a lecture or presentation without worrying about missing any part of it.
3. Record a song: sing a song during a meeting and save it later.
4. Record a demo: record a demonstration to demonstrate an app or share your knowledge with others.
5. Record a webinar: record a webinar and broadcast it.
6. Record a presentation: record a presentation and make it more dynamic.


7. Convert recording to image: extract the audio to save files for images.
8. Preview a video: view videos in small windows.


9. Edit the video with video editing tools: trim, crop, cut, enhance, or adjust the volume.
10. Change audio format: add or remove audio tracks.
11. Change video format: add or remove video tracks.


12. Share a file with a specified user: add your contacts to your files.
13. Share files with everyone: easily share files with your friends.
14. Share files with the cloud: upload

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